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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T40042 | Evifacotrep | TRP/TRPV Channel | |
Evifacotrep is a short transient receptor potential channel 5 ( TRPC5 ) antagonist (WO2020061162, compound 100). Evifacotrep can be used for the research of neurological diseases. | |||
T2298 | ML204 | TRP/TRPV Channel | |
ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. | |||
T22124 | Oleoyl Serotonin | TRP/TRPV Channel | |
Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM. | |||
T6848 | GSK1016790A | GSK101 | Calcium Channel , TRP/TRPV Channel |
GSK1016790A (GSK101) (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial cells. | |||
T6977 | SB-366791 | SB366791 | TRP/TRPV Channel |
SB-366791 is a new and selective cinnamide TRPV1 antagonist. | |||
T6617 | Optovin | TRP/TRPV Channel | |
Optovin is a TRPA1 activator, which is reversibly photoactivated. | |||
T1814 | ICILIN | AG-3-5 | TRP/TRPV Channel |
ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist. | |||
T10537 | BI-749327 | TRP/TRPV Channel | |
BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6). | |||
T5698 | TRPM8 antagonist 2 | TRP/TRPV Channel | |
TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes. | |||
T5640 | GSK2193874 | TRP/TRPV Channel | |
GSK2193874 was identified as a selective, orally active TRPV4 blocker. | |||
T12941 | SN 2 | TRP/TRPV Channel | |
SN 2 is a novel and potent TRPML3 ion channel activator(EC50 of 1.8±0.13 μM). | |||
T6660 | SB-705498 | TRP/TRPV Channel | |
SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis. | |||
T10300 | AMG2850 | TRP/TRPV Channel | |
AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8). | |||
T16763 | RN-1747 | TRP/TRPV Channel | |
RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 agonists (EC50: 0.77 μM, 4.0 μM, and 4.1 μM for hTRPV4, mTRPV4, and rTRPV4 respectively). RN-1747 also antagonizes TRPM8 (IC50: 4 μM... | |||
T9709 | TRPM8 antagonist 3 | TRP/TRPV Channel | |
TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM). | |||
T15628 | JT010 | TRP/TRPV Channel | |
JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM). | |||
T7430 | AM-0902 | TRP/TRPV Channel | |
AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1). | |||
T4680 | HC-067047 | HC067047 | TRP/TRPV Channel |
HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH . | |||
T8410 | ASP7663 | TRP/TRPV Channel | |
ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo. | |||
T5479 | AMG 333 | AMG-333 | TRP/TRPV Channel |
AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine. | |||
T7526 | JNJ-17203212 | TRP/TRPV Channel | |
JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM). | |||
T4385 | PF-4840154 | TRP/TRPV Channel | |
PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively. | |||
T1822 | Clemizole | HCV Protease , Histamine Receptor | |
Clemizole is an H1 histamine receptor antagonist, can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication. | |||
T9776 | TRPM4 inhibitor 8 | TRP/TRPV Channel | |
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion. | |||
T21623 | AS1269574 | AS 1269574 | GPR , TRP/TRPV Channel |
AS1269574 is a potent, orally available GPR119 agonist. AS1269574(AS 1269574) has the potential for the research of type 2 diabetes. | |||
T2007 | RQ-00203078 | TRP/TRPV Channel | |
RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist. | |||
T22360 | MDR-652 | TRP/TRPV Channel | |
MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1 respectively and EC50s for hTRPV1 and rTRPV1 ... | |||
T22537 | 9-Phenanthrol | TRP/TRPV Channel | |
9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel. | |||
T16532 | Pico145 | HC-608 | TRP/TRPV Channel |
Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits ( )-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells) It also shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, T... | |||
T16686 | Pyr10 | TRP/TRPV Channel | |
Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits... | |||
T12849 | SAR7334 | TRCP6-IN-1 | TRP/TRPV Channel |
T21543 | AP 18 | TRP/TRPV Channel | |
T24477 | MK6-83 | MK683 | TRP/TRPV Channel |
MK6-83 is the transient receptor potential channel ML3 agonist. | |||
T7102 | BCTC | TRP/TRPV Channel | |
BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively) | |||
T19723 | AMTB hydrochloride | AMTB | TRP/TRPV Channel |
AMTB hydrochloride (AMTB HCl) is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive refl... | |||
T11394 | GFB-8438 | TRP/TRPV Channel | |
GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively). | |||
T8528 | AC1903 | TRP/TRPV Channel | |
AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss. | |||
T16483 | PF-05105679 | TRP/TRPV Channel | |
PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain. | |||
T1822L | Clemizole hydrochloride | HCV Protease , Histamine Receptor | |
Clemizole hydrochloride is an antagonist for H1 histamine receptor. According to the research, Clemizole hydrochloride can inhibit hepatitis C virus (HCV) replication and NS4B's RNA binding. | |||
T7191 | Diphenyleneiodonium chloride | DPI | NOS , Reactive Oxygen Species , NADPH , TRP/TRPV Channel |
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity. | |||
T23322 | SB 452533 | TRP/TRPV Channel | |
SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8). | |||
T12306 | OMDM-5 | Cannabinoid Receptor , Endogenous Metabolite , TRP/TRPV Channel | |
OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM). | |||
T16014 | Mavatrep | JNJ-39439335 | TRP/TRPV Channel |
Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain. | |||
T4693 | 2-Aminoethyl diphenylborinate | 2-Aminoethoxydiphenyl borate,2-APB | Calcium Channel , TRP/TRPV Channel |
2-Aminoethyl diphenylborinate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations). | |||
T15758 | Linopirdine | DuP 996 | Potassium Channel , TRP/TRPV Channel |
Linopirdine (DuP 996) is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine is a cognitive enhancer. It acts by stimulating rel... | |||
T2711 | Chembridge-5861528 | TCS 5861528 | TRP/TRPV Channel |
Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively. | |||
T9247 | Vanilloid receptor antagonist 1 | 4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile | TRP/TRPV Channel |
Vanilloid receptor antagonist 1 (4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile) is a potent vanilloid receptor TRPV1 antagonist. | |||
T7205 | A-967079 | TRP/TRPV Channel | |
A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively. | |||
T0175 | Amiloride hydrochloride | Amiloride HCl,MK-870 hydrochloride | Apoptosis , Serine Protease , Sodium Channel , TRP/TRPV Channel |
Amiloride hydrochloride (Amiloride HCl) is an effective sodium channel blocker of epithelial. | |||
T7572 | RN-1734 | TRP/TRPV Channel | |
RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, mTRPV4 and rTRPV4,respectively) |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T7177 | Capsazepine | Apoptosis , TRP/TRPV Channel | |
Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) which activates the TRPV1 ion channel. It is ... | |||
T12514 | Podocarpic acid | Others , TRP/TRPV Channel | |
Podocarpic acid is a natural product and a novel TRPA1 activator. | |||
T6S1684 | 8-Gingerol | Antioxidant , Antibacterial , TRP/TRPV Channel | |
1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Gingerol shows antipyretic and anti-inflammation characteristic... | |||
T2807 | Caffeic Acid | Lipoxygenase , Endogenous Metabolite , TRP/TRPV Channel | |
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activities. | |||
TN4417 | Larixyl acetate | Others | |
Larixyl acetate is a bioactive chemical. | |||
TQ0001 | 1,4-Cineole | Isocineole | Endogenous Metabolite , TRP/TRPV Channel |
1,4-Cineole (Isocineole) is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1. | |||
TN1465 | Cannabigerol | NOS , 5-HT Receptor , ROS | |
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur... | |||
T3727 | Methyl syringate | Syringic Acid Methyl Ester | TRP/TRPV Channel |
Methyl syringate (Syringic Acid Methyl Ester) has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K. pictus is a specific and selec... | |||
T2952 | Camphor | (±)-Camphor,Bornan-2-one,2-Camphanone,2-Bornanone,Formosa | Influenza Virus , TRP/TRPV Channel |
Camphor (2-Camphanone) is a bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent. | |||
TCS0102 | Pulegone | (+)-Pulegone | Calcium Channel , Endogenous Metabolite , TRP/TRPV Channel |
1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a verapamil-sensitive psychostimulant effect t... | |||
T1407 | (-)-Menthol | L-Menthol,Levomenthol,Menthomenthol,Menthacamphor | Opioid Receptor , Endogenous Metabolite , TRP/TRPV Channel |
(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foo... | |||
TN1377 | α-Spinasterol | alpha-Spinasterol | COX , Antibacterial , TRP/TRPV Channel |
α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 v... | |||
T8307 | Hydroxy-α-sanshool | Hydroxy-α-sanshool | Endogenous Metabolite , TRP/TRPV Channel |
Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM). | |||
T2845 | Imperatorin | Ammidin,8-Isoamylenoxypsoralen,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen | TRP/TRPV Channel , AChR , AChE , NOD |
Imperatorin (8-Isopentenyloxypsoralene) is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo. | |||
T23107 | Ononetin | 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone | TRP/TRPV Channel |
Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM). | |||
T3865 | Beta-Eudesmol | Beta-Selinenol | TRP/TRPV Channel , AChR |
beta-Eudesmol (Beta-Selinenol) is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, including Cannabis, and has diverse biologica... | |||
T1321 | Nonivamide | Nonanoic acid vanillylamide,Pelargonic acid vanillylamide,Vanillyl-N-nonylamide,Pseudocapsaicin | TRP/TRPV Channel |
Nonivamide (Nonanoic acid vanillylamide) is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Nonivamide is an organic compound and a capsaicinoid. It is an ... | |||
T2994 | (E)-Cardamonin | Alpinetin chalcone,Cardamomin,Cardamonin,(E)-Cardamoni | Apoptosis , TRP/TRPV Channel |
(E)-Cardamonin (Alpinetin chalcone) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM... | |||
T0851 | Pregnenolone | 3β-Hydroxy-5-pregnen-20-one,Arthenolone | Cannabinoid Receptor , Endogenous Metabolite , TRP/TRPV Channel , AChR , Autophagy |
Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease. | |||
T14046 | Anandamide | (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide | Cannabinoid Receptor , Endogenous Metabolite |
Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous sy... | |||
T2163 | Dihydrocapsaicin | CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide | Others , TRP/TRPV Channel |
Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an... |